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Creative Commons license and disclaimer available from: 32 Both GIP and GLP-1 have been reported to exert direct effects on the cardiovascular system in addition to pancreatic beta cells

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Meta-analyses of GLP-1 receptor agonists show that approximately 25% of weight lost consists of lean mass, with 75% coming from fat mass

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This tells us the medication's therapeutic window is robustadherence and dose escalation matter far more than circadian timing