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Musculoskeletal & Anti-Inflammatory Effects GLP-1 receptors are present in: Chondrocytes Synovial tissues Macrophages Potential benefits include: Reduced inflammatory cytokines NF-B inhibition Reduced cartilage degradation Improvement in osteoarthritis inflammation The anti-inflammatory role of GLP-1 may become clinically important in rheumatologic and degenerative diseases

An improvement in gait speed was observed among participants with increased PCDNAmTL ( p = 0.012), suggesting that preservation or elongation of telomere length may be linked to better maintenance of physical function following semaglutide treatment

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