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doi: 10.1038/npp.2011.318 14 BelmakerR

However, genetic variants in GLP-1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) genes influence how strongly an individual's gut responds to these medications, explaining why some tolerate them better than others

These results suggest that GLP-1-based therapies suppress inflammatory cytokines and increase anti-inflammatory mediators in the pancreas

For most users, gastrointestinal side effects are most pronounced during the first few weeks and tend to improve as the body adjusts

The agency didn't immediately respond to CNBC's request for comment

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