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2025;33(4):769-780 4 Hartman ML, Sanyal AJ, Aleppo G, et al

Rheological characterization confirmed that incorporation of either TZP or Sema did not significantly alter the mechanical properties of the hydrogel, supporting formulation flexibility and robustness

It possesses in vitro balanced GIPR (EC50 = 3 pM) and GLP-1R (EC50 = 5 pM) agonism with relative activity seven times that of GIP to GIPR and five times that of GLP-1 to GLP-1R, respectively (44)

Understanding how semaglutide works can help explain why it is effective and why it might cause certain side effects, such as heart palpitations

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