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Researchers followed 173 patients with rheumatoid arthritis and a BMI of at least 27 who took semaglutide or tirzepatide, compared with 42 who were prescribed the medication but never started it

Semaglutide dramatically slows how quickly food moves from your stomach into your small intestine

Hormonal shifts, medication interactions, and underlying metabolic conditions like thyroid dysfunction can also trigger weight regain even during active treatment

[8] [9] This sympathetic activation may be mediated through central nervous system pathways, as GLP-1 receptors are present in the hypothalamus and brainstem regions that regulate cardiovascular function

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Tirzepatide (Zepbound) showed up to 22.5% in SURMOUNT-1