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N Engl J Med 377:644657 Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS (2019) Dapagliflozin and cardiovascular outcomes in type 2 diabetes

Celine Gounder explains what this means for patients

Activation of GLP-1R results in a rapid (seconds to minutes) potentiation of insulin secretion from islet beta cells which is achieved via rapid cAMP production, which results in the activation of protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac), and these two effectors modify several targets in the secretory machinery, resulting in enhanced insulin secretion 2,12

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Participants also experienced improvements in blood sugar control, blood pressure, and cholesterol markers alongside weight loss

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