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Key tips for underwriting applicants with GLP1 use Immediately look for: Evidence of the underlying diagnosis (as seen in medical claims, EHR, APS) Whether the GLP-1 is FDA-approved or off-label for that condition Signs of medication adherence (12 months, regular fills) Get cautious when: A GLP1 appears without any supporting clinical context Fills are intermittent or recently initiated Theres no alignment between the medication and expected companion therapies (e.g., no CPAP with sleep apnea) Be confident when: The diagnosis is clear The drug is first line and clinically appropriate Use has been stable long enough to confer benefit Kyle Schimek, PharmD Kyle Schimek is a board-certified pharmacist and Clinical Services Manager at Milliman IntelliScript

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Applying Occams razor to these results Data from the SELECT trial clearly demonstrated that semaglutide could reduce risk of MACE among patients with overweight or obesity, but the fact that participants on this drug also lost more weight raised a critical question as to whether we could truly interpret these results as evidence of an independent effect on CV health

The development of exendin-4 into the diabetes drug exenatide started the GLP-1RA, or GLP-1 receptor agonist, race