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Exposure to insulin is indicated to facilitate the removal of A in astrocytes through increased expression of IDE [150]

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As a unimolecular triple agonist, it targets the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG) receptors

Muscle weakness typically results from loss of lean body mass during rapid weight loss, with approximately 2540% of total weight lost coming from muscle rather than fat