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doi:10.1016/j.anl.2022.04.013
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Individual response to GLP-1 medications varies meaningfully variants in GLP1R (the GLP-1 receptor itself), GIPR (which matters specifically for tirzepatide's dual-agonist mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with different weight-loss curves and different tolerability profiles
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Injecting these substances poses a severe risk of infection, allergic reaction, and systemic toxicity
