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The authors reported statistically significant mean reductions in body weight from baseline across the retatrutide dose groups relative to placebo, with gastrointestinal adverse events the most frequently reported findings, consistent with the incretin-agonist class

A 12-week snapshot may underestimate the full effect of a given dose, whereas the 48-week results highlight just how powerful extended maintenance can be

While the weight loss data for retatrutide is exciting, the version being sold in gray market forums is often counterfeit retatrutide

Adequate protein intake is particularly important during weight loss to preserve muscle mass and support energy levels

doi: 10.1371/journal.pone.0158205 232 ChenSSunJZhaoGGuoAChenYFuRet al

Gut 55 (2), 243251