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Taking semaglutide and tirzepatide together can result in severe side effects

Geographic Availability Not available in AR, LA, MS, NM Clinical Oversight and Safety Licensed providers review all prescriptions for safety and accuracy

The new label includes references to some of those postmarketing risks, including intestinal obstruction, [and] severe constipation including fecal impaction. Some patients who took Zepbound have filed lawsuits, accusing Eli Lilly of failing to properly warn them that Zepbound could increase their risk of severe gut problems, including bowel obstructions, pancreatitis, and gastroparesis

doi: 10.1007/s00125-024-06144-1

In the SURMOUNT-1 trial, approximately 9% of participants on the highest 15mg dose did not achieve clinically meaningful weight loss of 5% or more

While oral tirzepatide options and orally disintegrating tablets are emerging, subcutaneous injection with a syringe continues to deliver the most reliable absorption and outcomes