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doi: 10.1055/s-0042-109065 Summary Keywords diabetes mellitus type 2, cardiovascular disease, cardiovascular risk, diabetic kidney disease, sodium-glucose cotransporter-2 inhibitor, glucagon-like peptide-1 receptor agonist, aldosterone, renin Citation Puglisi S, Rossini A, Poli R, Dughera F, Pia A, Terzolo M and Reimondo G (2021) Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists on Renin-Angiotensin-Aldosterone System

(2018) LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

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However, observational studies hint at possible protective effects, particularly in patients who achieve significant weight loss

Reduced abdominal pressure : Visceral fat pushes the diaphragm upward, reducing lung volume and making the airway more collapsible