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Goat anti-mouse HRP polymer (Mach 2 Mouse HRP-Polymer, Biocare Medical) and Vina Green Chromogen (Biocare Medical) were used for the staining

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Shortness of breath, a big weight gain, or swelling in the arms or legs

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Statistical methods Statistical analysis was conducted using One-way or Two-way ANOVA followed by Tukeys or Sidaks multiple comparison test or using Students t -test as specified in figure legends