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Clinical trials reported that combining semaglutide with lifestyle changes could result in an average loss of 15 to 20 percent body weight, making it one of the most effective medications for weight loss currently available

Mar 02, 2026, 07:01 ET Ozempic i s indicated as an adjunct to diet, exercise, and standard of care to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes and established cardiovascular disease and/or chronic kidney disease

The limited use of flozins and GLP-1 RAs in this cohort reflects the study period (pre-2019) and highlights that metformin was not competing with modern therapies

It also said it had concluded phase 3 trials using oral semaglutide in people to treat obesity

doi: 10.2337/db15-1547

Consult a nutritionist or healthcare provider for tailored guidance