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*FOR ORAL SEMAGLUTIDE USED FOR TYPE 2 DIABETES SOURCE: American Diabetes Association

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Cardiovascular and renal outcomes with canagliflozin according to baseline kidney function

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I 2 = 11

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The main differences between the two peptides are as follows: Mechanism of Action: Tirzepatide has an affinity to the receptors of another incretin hormone called Gastric Inhibitory Peptide (GIP) and also has some affinity to the GLP-1 receptors

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