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The Diabetes Prevention Program study showed that metformin reduced diabetes incidence by 31% and produced modest weight loss of 23 kg over three years

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Leptin treatment enhanced hepatic insulin sensitivity of the MKR mice by suppression of hepatic glucose production during the hyperinsulinemiceuglycemic clamp

In terms of weight loss at comparable time points, tirzepatide consistently outperforms semaglutide in clinical trials