small molecule glp 1 agonist Drug Hunter's 2023 Patent Review of GLP-1R Agonists | Drug Hunter posted on the topic BioWorld
Description
For weekly medications, the timing has less impact on side effects due to their steady-state pharmacokinetics
GIP and GLP-1 are also synthesized in the brain
Neth J Med (1990) 37:116
McKay J, Ho S, Jane M, Pal S
"Efficacy and safety of novel twincretin tirzepatide a dual GIP and GLP-1 receptor agonist in the management of type-2 diabetes: A Cochrane meta-analysis"
This effect was mediated by cAMP and PKA and was absent in mice with genetic deletion of the GLP-1R (54)
