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How fast and how often: the pharmacokinetics of drug use are decisive in addiction

Apart from the digestive system, GLP-1 is produced in the brain, especially in the nucleus tractus solitarius (NTS), where it functions as a neurotransmitter
isocitrate dehydrogenase, -ketoglutarate dehydrogenase, and succinate dehydrogenase, and at the same time reduced generation of reactive oxygen species stabilized the mitochondrial membrane potential, enhanced the levels of ATP, and enhanced the activity of the mitochondrial complex I [94]

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Beyond its glucose-lowering and weight-reducing effects, tirzepatide has been suggested to exhibit potential anti-atherosclerotic properties [22]

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