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However, no direct link has been found between GLP-1R agonists and higher pulmonary aspiration risk
Glucagon-like peptide 1 (GLP-1) is a cleavage product of the pre-proglucagon gene which is expressed in the -cells of the pancreas, the L-cells of the intestine, and neurons located in the caudal brainstem and hypothalamus
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Moreover, the efficacy of these drugs in MC4R KO mice aligns with clinical studies, indicating that MC4R KO mice serve as a reliable animal model for obesity research.
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