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Oncogene 30 , 907921 (2011)

In mice, the enzyme neprilysin additionally rapidly degrades the metabolites, making GLP-1 difficult to measure in this species [189]

Mentlein R, Dahms P, Grandt D, Krger R (1993) Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV

Am J Physiol Regul Integr Comp Physiol 2005

Obtaining coverage for Zepbound is limited to its FDA-approved indication

While practical challenges including cost, access, and manufacturing constraints currently limit the widespread adoption of tirzepatide, the clinical evidence suggests that dual agonism represents the future direction of metabolic therapy