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It is regarded as an activator of the PPAR nuclear receptor of the PPAR subgroup, which is mostly expressed in adipose tissue and associated with the reduction of inflammation, adipocyte differentiation, and lipid and glucose metabolism (Figure 8)

These drugs mimic a natural hormone called GLP-1, which helps regulate blood sugar and appetite

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Camp-mediated signaling promotes the mTOR pathway in beta cells, which induces HIF-1 translational activation