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But heres the thing: women with PCOS often have a weaker GLP-1 response due to higher body fat, low muscle mass, and hormonal imbalances

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14,38,39 Several therapies currently in clinical development target glucagon receptors in addition to incretin receptors due to the effects of glucagon on reducing food intake and increasing energy expenditure

Glucagon Cell Hyperplasia and Neoplasia With and Without Glucagon Receptor Mutations

"We estimated that most GLP-1 [drugs] increased risk for GERD," concluded the research team led by Laurent Azoulay, an associate professor with the Jewish General Hospital's Center for Clinical Epidemiology in Montreal, Canada