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Recent studies on Citrus aurantium indicate that the hexane fraction of CA (HFCA) stimulates NCI-H716 cells and induces membrane depolarization in NCI-H716, resulting in the secretion of glucagon-like peptide-1 (GLP-1), which regulates insulin secretion in pancreatic beta-cells

The model is summarised in Fig
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Beavers KM, et al

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