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When orforglipron does become available, it will likely fill a specific niche: people who want an oral option, people transitioning off injectables for maintenance, and people for whom needle-based treatment is not feasible

Gordon A, Dixit K, Shachi T, Salonia J, Seltzer E

These significant metabolic effects have made tirzepatide an important therapeutic option for patients with type 2 diabetes, particularly those who are overweight or obese

For tirzepatide, induction doses range from 10 to 15 mg weekly for active weight loss in many protocols, with typical maintenance doses reported to be around 5 to 7.5 mg weekly

This is why the STEP trial protocol includes two intermediate doses (1.7 mg) before reaching 2.4 mg, and why many people find their sweet spot below maximum

If you are planning to become pregnant, it is advised to stop taking the drug at least two months before trying to conceive
