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In rats, infusion of GRP stimulates the secretion of GLP-1 while administration of the GRP antagonist BW10 blocks GLP-1 secretion when fat is directly administered into the duodenum [339]
doi:10.1111/dom.13358 187
Evaluation of the effects of exenatide administration in patients with type 2 diabetes with worsened glycemic control caused by glucocorticoid therapy
The same group (Coskun et al
Because their peaks are lower and persistent, some patients find them more tolerable (less severe nausea spikes), though they still cause significant GI side effects in many
How GLP-1 Drugs Actually Work GLP-1 stands for Glucagon-Like Peptide-1, a hormone your gut naturally produces after eating
