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To prove the role of Gadd45a in the prefrontal cortex to influence the social behavior, we chose the region, mPFC, highly correlated with the processing of social information, to rescue the expression level of Gadd45a by stereotaxic injection of adenoviruses (AAV9-CAMKIIa-Gadd45a-EGFP) which could selectively overexpress Gadd45a in excitatory neurons (Fig