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At t = 180 min, subject consumed a fixed portion snack (cereal bar plus 125 ml orange juice (including 12 g of carbohydrate sugar)

The 2.4 mg target is based on trial data showing maximal efficacy at that dose, but individual optimization varies

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Both agents lower blood glucose through different mechanisms, and their simultaneous use could theoretically increase the risk of hypoglycemia, particularly in patients taking other antidiabetic medications such as insulin or sulfonylureas