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Hanyu H, Sato T, Kiuchi A, Sakurai H, Iwamoto T

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Retatrutide (LY3437943), developed by Eli Lilly, is a once-weekly injectable GIP/GLP-1/glucagon triple receptor agonist

Cardiovascular effects Heart rate increased by 5 to 10 beats per minute across the higher dose groups, peaking around week 24

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For RT-qPCRs, total RNA was extracted from liver and muscle using Nucleospin RNA kit (Macherey-Nagel, 740955.250), then reverse transcription was performed on 1 g of RNA using SensiFAST cDNA synthesis Kit (Meridian Biosciences, BIO-65053)
