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Retatrutide similarly lowered hemoglobin A1c (a diabetes marker) and even allowed some patients to discontinue blood pressure medications in trials

AUA Ganesan C, Kim SH, Chang TC, et al

Most are herbal, caffeine-based, or contain vague metabolic peptides with no peer-reviewed evidence

Oral Wegovy (Oral Semaglutide) For those favoring pills over injections, the oral Wegovy pill is a pioneering oral GLP-1 weight loss option, showing similar effectiveness to its injectable counterpart with a 16.6% average weight loss

The introduction of GLP-1 RAs for pediatric obesity represents both an opportunity and a challenge

Of note, the finding of a markedly greater benefit on HF of efpeglenatide amongst trial participants using SGLT2 inhibitors at enrolment in the AMPLITUDE-O CVOT highlights another important point (Lam et al., 2021)