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Tirzepatide is a peptide-based dual agonist that activates both GLP-1 and GIP receptors

GLP-1s are prescription-only, generally for BMI 30 or 27 with weight-related conditions

its longer-term safety record is by definition thinner because it has not completed phase 3 or accumulated post-market data the way tirzepatide has

If you have type 2 diabetes and are struggling to manage your blood sugar levels, especially if you are overweight or obese, GLP-1 shots may be an option to consider

Semaglutide treatment in diabetic rats increased myocardial SOD activity by 35% and reduced malondialdehyde levels, a marker of lipid peroxidation, by 45% [77]

It enrolled 17,604 adults aged 45 or older with a body mass index (BMI) of 27 kg/m2 or greater and preexisting CVD (prior MI, prior stroke or peripheral artery disease) without diabetes