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It's most effective when combined with lifestyle changes, such as improved diet and increased physical activity
Initially, the quality of observational studies was evaluated using the NewcastleOttawa Scale [22]
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Some OTC supplements contain caffeine, glucomannan, or other fiber-based ingredients with modest short-term effects, but none are validated for meaningful long-term weight loss
That said, common side effects such as loss of appetite, disordered sleep, or an upset stomach may indirectly make it more difficult to bounce back
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