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Meanwhile, western blot results confirmed that CGA treatment downregulated rotenone-induced phosphorylated alpha-synuclein levels by upregulating PI3K/AKT signaling and inactivating GSK-3 through the release of GLP-1

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Depletion of luminal Na+ did not affect l-valine-induced GLP-1 secretion (P>0.05), suggesting that co-transport of l-valine and Na+ is not important for the depolarization necessary to activate the voltage-gated Ca2+-channels

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Semaglutide typically shows measurable weight loss within 4 to 8 weeks, with most patients experiencing steady progress through weeks 12 to 16