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Mechanism In response to a previous FDA inquiry, two short-term mechanical studies were conducted using exenatide and liraglutide in a diabetic rat model, wherein one rat administered with exenatide died of pancreatic necrosis, while the others exhibited acinar-to-ductal metaplasia and ductal hyperplasia, indicative of potential premalignant alterations [62,63]

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Later, tissue paraffinization was performed in the Hadassah Ein-Kerem Pathology Department then transferred to paraffin blocks

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In addition, orlistat's potential to cause liver damage and its association with severe liver outcomes, such as gallstone formation, obstructive jaundice, and acute liver failure, have been documented [68, 70]

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