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Mechanism In response to a previous FDA inquiry, two short-term mechanical studies were conducted using exenatide and liraglutide in a diabetic rat model, wherein one rat administered with exenatide died of pancreatic necrosis, while the others exhibited acinar-to-ductal metaplasia and ductal hyperplasia, indicative of potential premalignant alterations [62,63]

Later, tissue paraffinization was performed in the Hadassah Ein-Kerem Pathology Department then transferred to paraffin blocks

However, subsequent research has demonstrated beneficial effects of GLP-1RAs in CRC

In addition, orlistat's potential to cause liver damage and its association with severe liver outcomes, such as gallstone formation, obstructive jaundice, and acute liver failure, have been documented [68, 70]