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These tirzepatide-related reductions in circulatory volumepressure overload and systemic inflammation may mitigate cardiorenal end-organ injury in people with HFpEF and obesity [85]

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Nevertheless, several important questions remain unanswered and require further investigation

As most discontinuations occurred during the rapid dose-escalation period of treatment, slower up-titration of dose may counter these

1984b Al-Suhail, A
