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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial

30 Increased intestinal transit is associated with specific microbiota species, 85 and patients with bile acid diarrhea effectively treated with colesevalam had a significantly greater abundance of Fusobacterium and Ruminococcus , both of which help convert primary to secondary bile acids

Setting realistic expectations based on mechanism and magnitude prevents disappointment and wasted money

All paraffin slides were deparaffinized and rehydrated before staining

Sokos GG, Bolukoglu H, German J, Hentosz T, Magovern Jr GJ, Maher TD, Dean DA, Bailey SH, Marrone G, Benckart DH, Elahi D, Shannon RP

Natural polysaccharides and proteins such as sodium alginate and albumin also serve as favorable carriers due to their low immunogenicity and strong biocompatibility [135]