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Stopping tirzepatide cold turkey and stopping semaglutide abruptly both carry significant risks including appetite rebound, gastrointestinal changes, mood shifts, and rapid weight regain

It includes a C-18 fatty acid chain attached to the peptide backbone that enables it to bind to albumin in the blood, extending its half-life to approximately one week

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doi: 10.1016/j.neuroscience.2009.08.009

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Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families