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Yet, beyond evaluating the pharmacokinetics (PK) and pharmacodynamics (PD) of hydrogel-based GLP-1 RA therapies, simple pharmacokinetic modeling can be used to predict drug release kinetics in more clinically relevant large animals and in humans, while also aiding in the design of biomaterial depot technologies ( 42 )
This is especially crucial with GLP-1s for weight loss due to the potential for reduced thirst and the need for adequate hydration to support fibers action and overall gut health while on GLP-1
If a dose is missed and the next planned dose is more than 48 hours away, the missed dose may generally be taken when remembered
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