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Long-term safety data continues to accumulate, though current evidence supports the medication's safety profile when used appropriately under medical supervision

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For the study, researchers evaluated the dermatologic and injection-site reaction safety of GLP-1RAs via a meta-analysis of randomised controlled trials (RCTs) and a disproportionality analysis of data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS)

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The relationship between obesity and bone metabolism is paradoxical, as increased mechanical loading is traditionally associated with higher bone mineral density, yet adiposity-driven chronic inflammation and metabolic dysfunction impair bone quality