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There were several factors varying between our patient and the other cases, particularly our patient also taking an SGLT2 inhibitor, but our case may suggest greater risk of EKA for a patient on synergistic regimens, Louwagie says

Side Effects and Medical Monitoring Common Side Effects to Expect When starting GLP-1 agonists, gastrointestinal issues are the most frequent side effects, especially in the early weeks or when increasing the dosage

Across major GLP-1 trialsincluding the STEP trials for weight loss and multiple cardiovascular outcome trialsirritability, anger, or aggression were not common adverse events, and rates were similar to placebo groups

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The effects of vertical sleeve gastrectomy in rodents are ghrelin independent