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Description
GLP-1RAs, approved for type 2 diabetes (T2DM), enhance incretin signaling to improve postprandial glucose metabolism

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Biochem 214 , 829835 (1993)

In both studies, stimuli with TNF and IL-1, respectively, led to decreased mitochondrial function, increased oxidative stress, increased levels of reactive oxygen species (ROS), increased expressions of proinflammatory cytokines (TNF, IL-1, IL-6, and IL-8) and expressions of matrix-metalloproteinase 1, 3, and 13, and upregulation of the p38/MAPK and p-65/NFB transcriptional complex expressions of the proinflammatory signalling pathways (Table 2) [39,40]
doi: 10.1016/j.numecd.2019.12.005

RCTs evaluating GLP-1 RA have not identified indicators of suicidality
