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Optimising blood glucose control is fundamental , as hyperglycaemia itself can delay gastric emptying and exacerbate symptoms

After repeated administration, rats in the short-access paradigm exhibited lower daily and cumulative METH intake than saline controls, with this effect becoming apparent on the second day of treatment and continuing throughout the study, while LIR did not affect METH-taking behavior in the extended-access paradigm

This is a starter dose and does not control blood sugar

Frias 2020 had one tirzepatide arm of 12 mg (which was analyzed as tirzepatide 10 mg arm) and two arms of tirzepatide 15 mg with different doseescalation patterns (outcome results were polled to analyze in a single tirzepatide 15 mg arm) [23]