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Both Wegovy and Zepbound target areas of the brain that regulate appetite and food intake

In animal research, giving Akkermansia to mice improved features of diet-induced metabolic problems (Everard et al., 2013), and a small human trial found that pasteurized Akkermansia was safe, well tolerated, and linked to some improved metabolic markers in adults with overweight or obesity (Depommier et al., 2019)

That said, participants who incorporated regular physical activity, particularly resistance training, tended to preserve more lean muscle mass during rapid weight loss

In human trials, most studies include participants who are screened to be overweight or obese, and diagnosed with different components of metabolic syndrome

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