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Key viscerosensory peptides released from the gut are the incretin hormones GLP-1 and gastric inhibitory peptide (GIP), CCK, and PYY [74, 84, 108], [109], [110]

For example, a study on liraglutide found it produced greater weight loss compared to metformin, with favorable impacts on menstrual regularity

Pharmaceuticals (Basel) 2024;17(4):525

While it looks at a very different (and more severe) health risk, the study is similar to Ozempics case in the sense that both aim to balance the trade-off between treating new and existing patients under supply uncertainty

Research shows that 12-hour sustained stimulation leads to marked receptor downregulation, meaning the cell actually destroys receptors rather than recycling them

Furthermore, many studies of ischemia/reperfusion animal models consistently revealed beneficial effects of GLP-1 on post-ischemia recovery and myocardial viability [13172224]