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Many require a prescription and work by influencing hunger hormones and blood sugar levels

2007 Jul;30(7):1709-16

The most discussed mechanism is in the brain

Age, baseline growth-hormone levels, sleep quality, nutrition, and training status all affect outcomes

[DOI] [PubMed] [Google Scholar] 37.Drucker D.J., Buse J.B., Taylor K., Kendall D.M., Trautmann M., Zhuang D., Porter L., DURATION-1 Study Group Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study

The signaling through GLP-1R leads to improved glycemic control and weight management, ultimately resulting in approval of GLP-1 receptor agonist medications for the treatment of T2DM and obesity [1]