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4 World Health Organization

Dietary bioactives derived from natural products have demonstrated significant promise in regulating metabolic pathways, including incretin secretion

Lillys pursuit of small-molecule GLP-1s like orforglipron indicates a strategic move to fully chemical manufacturing, which if successful could shift manufacturing out of peptide processes entirely

doi: 10.1016/j.foodchem.2017.01.056 200 WeiC-KTsaiY-HKorinekMHungP-HEl-ShazlyMChengY-Bet al

7 (2019): 11651172, 10.1093/cid/ciy1051

For compounded semaglutide (which comes in multi-dose vials rather than manufacturer pens), the same rules apply