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In addition, semaglutide use is not advised during pregnancy or breastfeeding, and women attempting to conceive should discontinue semaglutide medications at least two months prior to conception, as it can impact fertility.7 While there are typically no dose adjustments required for patients with renal or hepatic impairment, careful monitoring is advised for individuals who have had bariatric surgery

These medications can also improve lipotoxicity by reducing visceral adiposity and decreasing liver fat deposition, reducing insulin resistance and the development of non-alcoholic fatty liver diseases

Tissue-specific expression analysis aimed to identify the most affected tissues by highly expressed components of different versions of GLP1R networks: GLP1R, GLP1R/GIPR, GLP1R/GIP, GLP1R/GIPR/GCGR

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Appetite suppression, delayed gastric emptying, and altered absorption are all considered plausible contributors to increased micronutrient deficiency risk