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Diz-Chaves, Y., Herrera-Perez, S., Gonzalez-Matias, L

2017 Aug 31;377(9):839-848 Krishnan K, Raman S, Anand Moses CR, et al

Weight loss is associated with muscle loss

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Unlike endogenous GLP-1, which is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), Semaglutide is structurally modified to offer extended stability and a prolonged half-life in experimental models