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A clinician must determine whether treatment is appropriate

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Part II tested multiple administration as follows: eight healthy postmenopausal females were randomized 6:2 to receive IV doses of anti-ActA 10 mg/kg alone Q4W for four doses, or matching placebo

Among the anorexigenic peptides, the first recognized inhibitor of food intake in rodents (36) and then in humans (37-40) was cholecystokinin (CCK), the product of duodeno-jejunal endocrine I cells acting via CCK1 receptors on vagal afferent nerves