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Cesnik, E

Drugs that will produce 15 percent body weight loss we did not have that before in the medical therapy of obesity. With additional, potentially more effective GLP-1 receptor agonists coming online in the future, were at the beginning of a promising new chapter of obesity therapeutics

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Early GLP-1 development efforts were hindered by rapid degradation by dipeptidyl peptidase-4, short duration of action, and gastrointestinal intolerance at supraphysiologic exposure levels

Similar content being viewed by others Introduction Obesity represents a global public health crisis, with its prevalence continually rising and contributing to a myriad of comorbid conditions, including type 2 diabetes [1], cardiovascular diseases [2], and certain forms of cancer [3], that impact millions of people around the world

231 In non-randomized interventions, FIM therapies are associated with BMI reductions of 0.4 to 0.6 kg/m 2
