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Activation of these receptors can influence dopamine and serotonin signaling, theoretically creating conditions for mood changes in susceptible individuals

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There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis associated with GLP-1RA use compared to usual care

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Dickson S.L., Shirazi R.H., Hansson C., Bergquist F., Nissbrandt H., Skibicka K.P

1,5 PIONEER 4, PIONEER 2, and PIONEER 3 primary endpoint: Mean change in A1C from baseline at Week 26

Endocr Rev 33(6):9811030